The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female Apc ^Min/+ Mice.

ABSTRACT: Cancer cachexia is a multifactorial muscle wasting condition characterized by severe body weight and muscle mass loss which is secondary to chronic disease. The mechanistic examination of cachexia has predominately focused on the male phenotype and created significant gaps in understanding cachexia progression in the female. Female hypogonadism can accompany cancer cachexia and is characterized by reduced circulating 17ß-estradiol and uterine atrophy. Estrogen has known functions in skeletal muscle homeostasis involving the regulation of muscle protein turnover, cellular stressors, and oxidative metabolism. However, 17ß-estradiol's ability to regulate cachexia progression in the female is not known. The purpose of this study was to determine the effect of gonadal function and estradiol adm

SUBMITTER: Counts BR 

PROVIDER: S-EPMC6838005 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature