Protein Interactions Network of Hepatitis E Virus RNA and Polymerase With Host Proteins.

ABSTRACT: Host-pathogen interactions are crucial for the successful propagation of pathogens inside the host cell. Knowledge of interactions between host proteins and viral proteins or viral RNA may provide clues for developing novel antiviral strategies. Hepatitis E virus (HEV), a water-borne pathogen that causes acute hepatitis in humans, is responsible for epidemics in developing countries. HEV pathology and molecular biology have been poorly explored due to the lack of efficient culture systems. A contemporary approach, to better understand the viral infection cycle at the molecular level, is the use of system biology tools depicting virus-host interactions. To determine the host proteins which participate in the regulation of HEV replication, we indentified liver cell proteins interacting with

SUBMITTER: Kanade GD 

PROVIDER: S-EPMC6838024 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature