Mechanistic insights into autocrine and paracrine roles of endothelial GABA signaling in the embryonic forebrain.

ABSTRACT: The developing cerebral cortex uses a complex developmental plan involving angiogenesis, neurogenesis and neuronal migration. Our recent studies have highlighted the importance of endothelial cell secreted GABA signaling in the embryonic forebrain and established novel autonomous links between blood vessels and the origin of neuropsychiatric diseases. A GABA pathway operates in both endothelial cells and GABAergic neurons of the embryonic telencephalon; however, while the neuronal GABA pathway has been extensively studied, little is known about the endothelial GABA pathway. Our recently generated Vgat endothelial cell knockout mouse model that blocks GABA release from endothelial cells, serves as a new tool to study how endothelial GABA signaling shapes angiogenesis and neurovascular inter

SUBMITTER: Choi YK 

PROVIDER: S-EPMC6838150 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature