Changes of urine metabolite profiles are induced by inactivated influenza vaccine inoculations in mice.

ABSTRACT: The safety evaluation of vaccines is critical to avoid the development of side effects in humans. To increase the sensitivity of detection for toxicity tests, it is important to capture not only pathological changes but also physiological changes. ¹H nuclear magnetic resonance (NMR) spectroscopy analysis of biofluids produces profiles that show characteristic responses to changes in physiological status. In this study, mouse urine metabolomics analysis with ¹H NMR was performed using different influenza vaccines of varying toxicity to assess the usefulness of ¹H NMR in evaluating vaccine toxicity. Two types of influenza vaccines were used as model vaccines: a toxicity reference vaccine (RE) and a hemagglutinin split vaccine. According to the blood biochemic

SUBMITTER: Sasaki E 

PROVIDER: S-EPMC6838172 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature