Changes in oncogenic protein levels in peri-implant oral malignancy: a case report.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors.

Case presentation

A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient's preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC).

Conclusions

The protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met,

SUBMITTER: Seo MH 

PROVIDER: S-EPMC6838285 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature