Ontology highlight
ABSTRACT:
SUBMITTER: Cross M
PROVIDER: S-EPMC6838324 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cross Megan M York Mark M Długosz Ewa E Straub Jan Hendrik JH Biberacher Sonja S Herath H M P Dilrukshi HMPD Logan Stephanie A SA Kim Jeong-Sun JS Gasser Robin B RB Ryan John H JH Hofmann Andreas A
Scientific reports 20191107 1
Protein-based drug discovery strategies have the distinct advantage of providing insights into the molecular mechanisms of chemical effectors. Currently, there are no known trehalose-6-phosphate phosphatase (TPP) inhibitors that possess reasonable inhibition constants and chemical scaffolds amenable to convenient modification. In the present study, we subjected recombinant TPPs to a two-tiered screening approach to evaluate several diverse compound groups with respect to their potential as TPP i ...[more]