Validation of a host response test to distinguish bacterial and viral respiratory infection.

ABSTRACT:

Background

Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform nor extensively tested. Here, we validate a microarray-derived host response signature and explore performance in microbiology-negative and coinfection cases.

Methods

Subjects with acute respiratory illness were enrolled in participating emergency departments. Reference standard was an adjudicated diagnosis of bacterial infection, viral infection, both, or neither. An 87-transcript signature for distinguishing bacterial, viral, and noninfectious illness was measured from peripheral blood using RT-PCR. Performance characteristics were evaluated in subjects wi

SUBMITTER: Lydon EC 

PROVIDER: S-EPMC6838360 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature