Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy.

ABSTRACT:

Background

Non-ischemic dilated cardiomyopathy (NIDCM) responds variably to intramyocardial injection of mesenchymal stem cells (MSCs). We hypothesized that NIDCM genotype may influence responsiveness to MSC therapy and performed genotyping on all patients in the POSEIDON-DCM trial.

Methods

POSEIDON-DCM patients (n = 34) underwent genetic sequence analysis and deletion/duplication testing. The results were classified as positive for pathological variants (PV+; n = 8), negative for any variants (V-; n = 6), or as variants of uncertain significance (VUS; n = 20). All outcomes of therapy were analysed for each category of genetic results.

Findings

The 3 groups were indistinguishable at baseline with regard to ejection fraction (EF), demographics, medication use, or funct

SUBMITTER: Rieger AC 

PROVIDER: S-EPMC6838383 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature