Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer.

ABSTRACT:

Background

Despite treatment advances, there remains a significant risk of recurrence in ovarian cancer, at which stage it is usually incurable. Consequently, there is a clear need for improved patient stratification. However, at present clinical prognosticators remain largely unchanged due to the lack of reproducible methods to identify high-risk patients.

Methods

In high-grade serous ovarian cancer patients with advanced disease, we spatially define a tumour ecological balance of stromal resource and immune hazard using high-throughput image and spatial analysis of routine histology slides. On this basis an EcoScore is developed to classify tumours by a shift in this balance towards cancer-favouring or inhibiting conditions.

Findings

The EcoScore provides prognostic

SUBMITTER: Nawaz S 

PROVIDER: S-EPMC6838425 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature