High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation.

ABSTRACT:

Background

Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determine if urea accumulation in brain is a key factor causing depression using clinical data and animal models.

Methods

A meta-analysis was used to identify the relationship between depression and chronic diseases. Functional Magnetic Resonance Imaging (fMRI) brain scans and common biochemical indexes were compared between the patients and healthy controls. We used behavioural tests, electrophysiology, and molecular profiling techniques to investigate the functional

SUBMITTER: Wang H 

PROVIDER: S-EPMC6838447 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature