Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel.

ABSTRACT: Obstructing conductive pathways of the channel-forming toxins with targeted blockers is a promising drug design approach. Nearly all tested positively charged ligands have been shown to reversibly block the cation-selective channel-forming protective antigen (PA₆₃) component of the binary anthrax toxin. The cationic ligands with more hydrophobic surfaces, particularly those carrying aromatic moieties, inhibited PA₆₃ more effectively. To understand the physical basis of PA₆₃ selectivity for a particular ligand, detailed information is required on how the blocker structural elements (e.g., positively charged and aromatic groups) influence the molecular kinetics of the blocker/channel binding reactions. In this study, we address this problem using the high-res

SUBMITTER: Momben Abolfath S 

PROVIDER: S-EPMC6838753 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature