Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure.

ABSTRACT: Chronic wounds-including diabetic foot ulcers, venous leg ulcers, and pressure ulcers-represent a major health problem that demands an urgent solution and new therapies. Despite major burden to patients, health care professionals, and health care systems worldwide, there are no efficacious therapies approved for treatment of chronic wounds. One of the major obstacles in achieving wound closure in patients is the lack of epithelial migration. Here, we used multiple pre-clinical wound models to show that Caveolin-1 (Cav1) impedes healing and that targeting Cav1 accelerates wound closure. We found that Cav1 expression is significantly upregulated in wound edge biopsies of patients with non-healing wounds, confirming its healing-inhibitory role. Conversely, Cav1 was absent from the migrating e

SUBMITTER: Jozic I 

PROVIDER: S-EPMC6838864 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature