In silico characterization of hypothetical proteins from Orientia tsutsugamushi str. Karp uncovers virulence genes.

ABSTRACT: Scrub typhus also known as bush typhus is a disease with symptoms similar to Chikungunya infection. It is caused by a gram-negative bacterium Orientia tsutsugamushi which resides in its vertebrate host, Mites. The genome of Orientia tsutsugamushi str. Karp encodes for 1,563 proteins, of which 344 are characterized as hypothetical ones. In the present study, we tried to identify the probable functions of these 344 hypothetical proteins (HPs). All the characterized hypothetical proteins (HPs) belong to the various protein classes like enzymes, transporters, binding proteins, metabolic process and catalytic activity and kinase activity. These hypothetical proteins (HPs) were further analyzed for virulence factors with 62 proteins identified as the most virulent proteins among th

SUBMITTER: Imam N 

PROVIDER: S-EPMC6838952 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature