Genome-wide association analysis reveals QTL and candidate mutations involved in white spotting in cattle.

ABSTRACT:

Background

White spotting of the coat is a characteristic trait of various domestic species including cattle and other mammals. It is a hallmark of Holstein-Friesian cattle, and several previous studies have detected genetic loci with major effects for white spotting in animals with Holstein-Friesian ancestry. Here, our aim was to better understand the underlying genetic and molecular mechanisms of white spotting, by conducting the largest mapping study for this trait in cattle, to date.

Results

Using imputed whole-genome sequence data, we conducted a genome-wide association analysis in 2973 mixed-breed cows and bulls. Highly significant quantitative trait loci (QTL) were found on chromosomes 6 and 22, highlighting the well-established coat color genes KIT and MITF as likely

SUBMITTER: Jivanji S 

PROVIDER: S-EPMC6839108 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature