A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke.

ABSTRACT:

Background

The microRNA-17-92 (miR-17-92) cluster is one of the most extensively studied miRNA clusters. Abnormal expression of the cluster has been found to play important role in different kinds of human diseases, including ischemic stroke (IS). The aim of our study was to investigate the association between three polymorphisms (rs1491034, rs9301654 and rs982873) in the promoter of the miR-17-92 cluster and risk of IS.

Methods

Three hundred and ninety-eight patients with IS and 397 control subjects were included. The genotypes of the three polymorphisms were determined by Snapshot SNP genotyping assay. Relative expression of the cluster in peripheral blood mononuclear cells (PBMCs) of cases and controls were examined by quantitative real-time PCR.

Results

Significan

SUBMITTER: Huang H 

PROVIDER: S-EPMC6839137 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature