Organoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review.

ABSTRACT: Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer in developed countries, indicating the need for further research. Although current cancer models prove useful, they have major limitations. Organoids, a novel in vitro 3D cell culture technique, derived from stem cells, could provide a bridge between the current preclinical platforms. However, this technique is still in its early stages. After conducting a systematic literature search, only sixteen manuscripts concerning ovarian related organoids could be retrieved.In this review, we discuss current tumor models, including organoids and provide a comprehensive review about organoids of ovarian tissue. Potential future applications are addressed, proving organoids to be an interesting platform for modeling tumorige

SUBMITTER: Dumont S 

PROVIDER: S-EPMC6839218 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature