Integrative analysis of transcriptomic data related to the liver of laying hens: from physiological basics to newly identified functions.

ABSTRACT:

Background

At sexual maturity, the liver of laying hens undergoes many metabolic changes to support vitellogenesis. In published transcriptomic approaches, hundreds of genes were reported to be overexpressed in laying hens and functional gene annotation using gene ontology tools have essentially revealed an enrichment in lipid and protein metabolisms. We reanalyzed some data from a previously published article comparing 38-week old versus 10-week old hens to give a more integrative view of the functions stimulated in the liver at sexual maturity and to move beyond current physiological knowledge. Functions were defined based on information available in Uniprot database and published literature.

Results

Of the 516 genes previously shown to be overexpressed in the liver of lay

SUBMITTER: Gloux A 

PROVIDER: S-EPMC6839265 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature