Interleukin 18 Polymorphisms and its serum level in Patients with Multiple Sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed.

Propose

To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518, rs360719, and rs187238).

Methods

In this case-control study, 110 MS patients diagnosed according to the McDonald criteria and 110 healthy individuals were recruited. IL-18 gene polymorphisms were genotyped by polymerase chain reaction high-resolution melt test, and IL-18 serum level was determined by enzyme-linked immunosorbent assay technique.

Results

The mean age of the MS patients (89 females and 21 males) and th

SUBMITTER: Jahanbani-Ardakani H 

PROVIDER: S-EPMC6839318 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature