Organ sparing of linac-based targeted marrow irradiation over total body irradiation.

ABSTRACT:

Purpose

Targeted marrow irradiation (TMI) is an alternative conditioning regimen to total body irradiation (TBI) before bone marrow transplantation in hematologic malignancies. Intensity-modulation methods of external beam radiation therapy are intended to permit significant organ sparing while maintaining adequate target coverage, improving the therapeutic ratio. This study directly compares the dose distributions to targets and organs at risk from TMI and TBI, both modalities conducted by general-use medical linacs at our institution.

Methods

TMI treatments were planned for 10 patients using multi-isocentric feathered volumetric arc therapy (VMAT) plans, delivered by 6 MV photon beams of Elekta Synergy linacs. The computed tomography (CT) datasets used to obtain these plan

SUBMITTER: Warrell GR 

PROVIDER: S-EPMC6839384 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature