Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial.

ABSTRACT:

Context

Saturated fatty acid (SFA) vs polyunsaturated fatty acid (PUFA) may promote nonalcoholic fatty liver disease by yet unclear mechanisms.

Objective

To investigate if overeating SFA- and PUFA-enriched diets lead to differential liver fat accumulation in overweight and obese humans.

Design

Double-blind randomized trial (LIPOGAIN-2). Overfeeding SFA vs PUFA for 8 weeks, followed by 4 weeks of caloric restriction.

Setting

General community.

Participants

Men and women who are overweight or have obesity (n = 61).

Intervention

Muffins, high in either palm (SFA) or sunflower oil (PUFA), were added to the habitual diet.

Main outcome measures

Lean tissue mass (not reported here). Secondary and exploratory outcomes included liver and ectopic fat

SUBMITTER: Rosqvist F 

PROVIDER: S-EPMC6839433 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature