In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization.

ABSTRACT: Photoswitchable oligonucleotides can determine specific biological outcomes by light-induced conformational changes. In particular, artificial probes activated by visible-light irradiation are highly desired in biological applications. Here, we report two novel types of visible-light photoswitchable peptide nucleic acids (PNAs) based on the molecular transducers: hemithioindigo and tetra-ortho-fluoroazobenzene. Our study reveals that the tetra-ortho-fluoroazobenzene-PNA conjugates have promising properties (fast reversible isomerization, exceptional thermal stability, high isomer conversions and sensitivity to visible-light irradiation) as reversible modulators to control oligonucleotide hybridization in biological contexts. Furthermore, we verified that this switchable modification delive

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6839558 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature