Application of new statistical distribution approaches for environmental mixture risk assessment: A case study.

ABSTRACT:

Objectives

There is growing evidence that single substances present below their individual thresholds of effect may still contribute to combined effects. In component-based mixture risk assessment (MRA), the risks can be addressed using information on the mixture components. This is, however, often hampered by limited availability of ecotoxicity data. Here, the possible use of ecotoxicological threshold concentrations of no concern (i.e. 5th percentile of statistical distribution of ecotoxicological values) is investigated to fill data gaps in MRA.

Methods

For chemicals without available aquatic toxicity data, ecotoxicological threshold concentrations of no concern have been derived from Predicted No Effect Concentration (PNEC) distributions and from chemical toxicity distri

SUBMITTER: Kienzler A 

PROVIDER: S-EPMC6839615 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature