Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial.

ABSTRACT:

Objective

To investigate whether a whole grain diet alters the gut microbiome and insulin sensitivity, as well as biomarkers of metabolic health and gut functionality.

Design

60 Danish adults at risk of developing metabolic syndrome were included in a randomised cross-over trial with two 8-week dietary intervention periods comprising whole grain diet and refined grain diet, separated by a washout period of ≥6 weeks. The response to the interventions on the gut microbiome composition and insulin sensitivity as well on measures of glucose and lipid metabolism, gut functionality, inflammatory markers, anthropometry and urine metabolomics were assessed.

Results

50 participants completed both periods with a whole grain intake of 179±50 g/day and 13±10 g/day in the whole gr

SUBMITTER: Roager HM 

PROVIDER: S-EPMC6839833 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature