Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births.

ABSTRACT: Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood. Histopathological studies of preterm birth suggest advanced villous maturity may have a role in idiopathic spontaneous preterm birth (isPTB). To better understand pathological and molecular basis of isPTB, we compared placental villous transcriptomes from carefully phenotyped cohorts of PTB due to infection or isPTB between 28-36 weeks gestation and healthy term placentas. Transcriptomic analyses revealed a unique expression signature for isPTB distinct from the age-matched controls that were delivered prematurely due to infection. This signature included the upregulation of three IGF binding proteins (IGFBP1, IGFBP2, and IGFBP6), supp

SUBMITTER: Brockway HM 

PROVIDER: S-EPMC6839872 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature