Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method.

ABSTRACT: PURPOSE:To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS). METHODS:We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F:M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor. RESULTS:The standard method of analysis o

SUBMITTER: Boquete L 

PROVIDER: S-EPMC6839873 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature