Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology.

ABSTRACT: Multiple animal models have been created to gain insight into Alzheimer's disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD, resulting in the formation of amyloid β plaques, one of the pathological hallmarks observed in AD patients. However, recent evidence suggests that the overexpression of APP by itself can confound some of the reported observations. Therefore, we investigated in the present study the App^NL-G-Fmodel, an App knock-in (App-KI) mouse model that develops amyloidosis in the absence of APP-overexpression. Our findings at the behavioral, electrophysiological, and histopathological level confirmed an age-dependent increase in Aβ1-42 levels and plaqu

SUBMITTER: Jacob S 

PROVIDER: S-EPMC6841667 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature