Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Angiopoietin-1 (Ang-1) and 2 (Ang-2), high mobility group box 1 (HMGB1), soluble receptor for advanced glycation endproducts (sRAGE), soluble triggering receptor expressed on myeloid cells 1 (sTREM1), and soluble urokinase-type plasminogen activator receptor (suPAR) have shown promising results for predicting all-cause mortality in critical care patients. The aim of our systematic review and meta-analysis was to assess the prognostic value of these biomarkers for mortality in adult patients with sepsis. METHODS:A systematic literature search of the MEDLINE, PubMed, EMBASE, and Cochrane Library databases, for articles in English published from 01.01.1990 onwards, was conducted. The systematic review focused exclusively on observational studies of adult patients with sepsis, any r

SUBMITTER: Pregernig A 

PROVIDER: S-EPMC6841861 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature