Amino acid substitution scoring matrices specific to intrinsically disordered regions in proteins.

ABSTRACT: An amino acid substitution scoring matrix encapsulates the rates at which various amino acid residues in proteins are substituted by other amino acid residues, over time. Database search methods make use of substitution scoring matrices to identify sequences with homologous relationships. However, widely used substitution scoring matrices, such as BLOSUM series, have been developed using aligned blocks that are mostly devoid of disordered regions in proteins. Hence, these substitution-scoring matrices are mostly inappropriate for homology searches involving proteins enriched with disordered regions as the disordered regions have distinct amino acid compositional bias, and therefore expected to have undergone amino acid substitutions that are distinct from those in the ordered regions. We,

SUBMITTER: Trivedi R 

PROVIDER: S-EPMC6841959 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature