Ontology highlight
ABSTRACT:
SUBMITTER: Pena CJ
PROVIDER: S-EPMC6841985 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191108 1
Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain's transcript ...[more]