Disrupted Habituation in the Early Stage of Psychosis.

ABSTRACT:

Background

Learning and memory are impaired in schizophrenia. Some theories have proposed that one form of memory, habituation, is particularly impaired. Preliminary evidence suggests that memory impairment is associated with failed hippocampal habituation in patients with chronic schizophrenia. We studied how abnormal habituation of the hippocampus is related to relational memory deficits in the early stage of psychosis.

Methods

We measured hippocampal activity in 62 patients with early psychosis and 70 healthy individuals using functional magnetic resonance imaging. Habituation was defined as the slope of functional magnetic resonance imaging signal change to repeated presentations of faces and objects. Relational memory ability was measured as the slope of preferential vi

SUBMITTER: Avery SN 

PROVIDER: S-EPMC6842099 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature