Functional Logic of Layer 2/3 Inhibitory Connectivity in the Ferret Visual Cortex.

ABSTRACT: Understanding how cortical inhibition shapes circuit function requires identifying the connectivity rules relating the response properties of inhibitory interneurons and their postsynaptic targets. Here we explore the orientation tuning of layer 2/3 inhibitory inputs in the ferret visual cortex using a combination of in vivo axon imaging, functional input mapping, and physiology. Inhibitory boutons exhibit robust orientation-tuned responses with preferences that can differ significantly from the cortical column in which they reside. Inhibitory input fields measured with patterned optogenetic stimulation and intracellular recordings revealed that these inputs originate from a wide range of orientation domains, inconsistent with a model of co-tuned inhibition and excitation. Intracellular sy

SUBMITTER: Scholl B 

PROVIDER: S-EPMC6842115 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature