Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

ABSTRACT: BACKGROUND:Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility. Previous studies have shown some possible yet conflicting links between family history of cancer and EGFR mutation in lung cancer. As EGFR-mutated lung cancer favours female, never-smoker, adenocarcinoma and Asians, it may be argued that there may be some underlying genetic modifiers responsible for the pathogenesis of EGFR mutation. METHODS:We searched four databases for all original articles on family history of malignancy and EGFR mutation status in lung cancer published up to July 2018. We performed a meta-analysis by using a random-effects model and odds ratio estimates. Heterogeneity and sensitivity were also investigated. Then we conducted a second literature research to curate case reports of familial lung cancers who studied both germline cancer predisposing genes and their somatic EGFR mutation status; and explored the possible links between cancer predisposing genes and EGFR mutation. RESULTS:Eleven studies have been included in the meta-analysis. There is a significantly higher likelihood of EGFR mutation in lung cancer patients with family history of cancer than their counterparts without family history, preferentially in Asians (OR?=?1.35[1.06-1.71], P?=?0.01), those diagnosed with adenocarcinomas ((OR?=?1.47[1.14-1.89], P?=?0.003) and those with lung cancer-affected relatives (first and second-degree: OR?=?1.53[1.18-1.99], P?=?0.001; first-degree: OR?=?1.76[1.36-2.28, P?

SUBMITTER: Cheng YI 

PROVIDER: S-EPMC6842246 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature