Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

ABSTRACT:

Background

Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility. Previous studies have shown some possible yet conflicting links between family history of cancer and EGFR mutation in lung cancer. As EGFR-mutated lung cancer favours female, never-smoker, adenocarcinoma and Asians, it may be argued that there may be some underlying genetic modifiers responsible for the pathogenesis of EGFR mutation.

Methods

We searched four databases for all original articles on family history of malignancy and EGFR mutation status in lung cancer published up to July 2018. We performed a meta-analysis by using a random-effects model and odds r

SUBMITTER: Cheng YI 

PROVIDER: S-EPMC6842246 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature