Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma.

ABSTRACT:

Background

In infants, distinct nasopharyngeal bacterial microbiotas differentially associate with the incidence and severity of acute respiratory tract infection and childhood asthma development.

Objective

We hypothesized that distinct nasal airway microbiota structures also exist in children with asthma and relate to clinical outcomes.

Methods

Nasal secretion samples (n = 3122) collected after randomization during the fall season from children with asthma (6-17 years, n = 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S rRNA profiling. Statistical analyses with exacerbation as the primary outcome and rhinovirus infection and respiratory illnesses as secondary outcomes were performed. Using A549 epithelial cells, we assessed nasal isolates of Moraxella

SUBMITTER: McCauley K 

PROVIDER: S-EPMC6842413 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature