Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring.

ABSTRACT:

Background/objectives

Adiponectin concentrations are low in obese pregnant women. Restoring normal adiponectin concentrations by infusion in obese pregnant mice prevents placental dysfunction, foetal overgrowth and metabolic syndrome in the offspring. We hypothesised that normalising maternal adiponectin in obese late pregnant dams prevents cardiac dysfunction in the adult offspring.

Subjects/methods

Pregnant female mice with diet-induced obesity were infused with adiponectin (0.62 μg g^-1 day^-1, n = 24) or saline (n = 22) over days 14.5-18.5 of pregnancy (term = day 19.5). Control dams ate standard chow and received saline (n = 22). Offspring were studied at 3 and 6 months of age.

Results

Maternal obesity impaired ventricular diastolic function,

SUBMITTER: Vaughan OR 

PROVIDER: S-EPMC6842414 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature