Associations between fungal and bacterial microbiota of airways and asthma endotypes.

ABSTRACT:

Background

The relationship between asthma, atopy, and underlying type 2 (T2) airway inflammation is complex. Although the bacterial airway microbiota is known to differ in asthmatic patients, the fungal and bacterial markers that discriminate T2-high (eosinophilic) and T2-low (neutrophilic/mixed-inflammation) asthma and atopy are still incompletely identified.

Objectives

The aim of this study was to demonstrate the fungal microbiota structure of airways in asthmatic patients associated with T2 inflammation, atopy, and key clinical parameters.

Methods

We collected endobronchial brush (EB) and bronchoalveolar lavage (BAL) samples from 39 asthmatic patients and 19 healthy subjects followed by 16S gene and internal transcribed spacer-based microbiota sequencing. The micr

SUBMITTER: Sharma A 

PROVIDER: S-EPMC6842419 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature