Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition.

ABSTRACT: Schizophrenia is associated with amotivation and reduced goal-directed behavior, which have been linked to poor functional outcomes. Motivational deficits in schizophrenia are often measured using effort-based decision-making (EBDM) paradigms, revealing consistent alterations in effort expenditure relative to controls. Although these results have generally been interpreted in terms of decreased motivation, the ability to use trial-by-trial changes in reward magnitude or probability of receipt to guide effort allocation may also be affected by cognitive deficits. To date, it remains unclear whether altered performance in EBDM primarily reflects deficits in motivation, cognitive functioning, or both. We applied a newly developed computational modeling approach to the analysis of EBDM data fr

SUBMITTER: Cooper JA 

PROVIDER: S-EPMC6842449 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature