Copy number variation is highly correlated with differential gene expression: a pan-cancer study.

ABSTRACT: BACKGROUND:Cancer is a heterogeneous disease with many genetic variations. Lines of evidence have shown copy number variations (CNVs) of certain genes are involved in development and progression of many cancers through the alterations of their gene expression levels on individual or several cancer types. However, it is not quite clear whether the correlation will be a general phenomenon across multiple cancer types. METHODS:In this study we applied a bioinformatics approach integrating CNV and differential gene expression mathematically across 1025 cell lines and 9159 patient samples to detect their potential relationship. RESULTS:Our results showed there is a close correlation between CNV and differential gene expression and the copy number displayed a positive linear influence on gene ex

SUBMITTER: Shao X 

PROVIDER: S-EPMC6842483 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature