Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy.

ABSTRACT:

Background

A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor.

Aim

CLINICAL REPORT: An 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria.

Methods

Microbiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy.

Results

During the treatment course, a progressive he

SUBMITTER: Venosi S 

PROVIDER: S-EPMC6842486 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature