Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database.

ABSTRACT: BACKGROUND:High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks and survival benefits of different strategies treated in this group. METHODS:Octogenarians (≥80 years) with resectable proximal gastric carcinoma who were recommended for surgery were identified from National Cancer Database during 2004-2013. RESULTS:Patients age ≥ 80 years with PGC were less likely to be recommended or eventually undergo surgery compared to younger patients. Patients with surgery had a significantly better survival than those without surgery (5-year OS: 26% vs. 7%, p < 0.001), especially in early stage patients. However, additional chemotherapy (HR: 0.94, 95

SUBMITTER: Wang X 

PROVIDER: S-EPMC6842542 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature