Global selective sweep of a highly inbred genome of the cattle parasite <i>Neospora caninum</i>.

ABSTRACT: Neospora caninum, a cyst-forming apicomplexan parasite, is a leading cause of neuromuscular diseases in dogs as well as fetal abortion in cattle worldwide. The importance of the domestic and sylvatic life cycles of Neospora, and the role of vertical transmission in the expansion and transmission of infection in cattle, is not sufficiently understood. To elucidate the population genomics of Neospora, we genotyped 50 isolates collected worldwide from a wide range of hosts using 19 linked and unlinked genetic markers. Phylogenetic analysis and genetic distance indices resolved a single genotype of N. caninum Whole-genome sequencing of 7 isolates from 2 different continents identified high linkage disequilibrium, significant structural variation, but only limited po

SUBMITTER: Khan A 

PROVIDER: S-EPMC6842595 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature