Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch.

ABSTRACT: The reactivation of quiescent cells to proliferate is fundamental to tissue repair and homeostasis in the body. Often referred to as the G0 state, quiescence is, however, not a uniform state but with graded depth. Shallow quiescent cells exhibit a higher tendency to revert to proliferation than deep quiescent cells, while deep quiescent cells are still fully reversible under physiological conditions, distinct from senescent cells. Cellular mechanisms underlying the control of quiescence depth and the connection between quiescence and senescence are poorly characterized, representing a missing link in our understanding of tissue homeostasis and regeneration. Here we measured transcriptome changes as rat embryonic fibroblasts moved from shallow to deep quiescence over time in the absence of

SUBMITTER: Fujimaki K 

PROVIDER: S-EPMC6842626 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature