The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in Apc^Min mice.

ABSTRACT: Tumor multiplicity in the Apc^Min (Min) mouse model of CRC is a classic quantitative trait that is subject to complex genetic and environmental factors, and therefore serves as an ideal platform to study modifiers of disease. While disparate inbred genetic backgrounds have well-characterized modifying effects on tumor multiplicity, it is unclear whether more closely related backgrounds such as C57BL/6J and C57BL6/N differentially modify the phenotype. Furthermore, it is unknown whether the complex gut microbiota (GM) influences the effects of these background strains. We assessed tumor multiplicity in F1 mice generated from the original Min colony from the McArdle Laboratory at the University of Wisconsin (C57BL/6JMlcr-Apc^Min) crossed with either C57BL/6J or C57BL/6N w

SUBMITTER: Moskowitz JE 

PROVIDER: S-EPMC6842652 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature