Maternal exposure to outdoor air pollution and congenital limb deficiencies in the National Birth Defects Prevention Study.

ABSTRACT:

Background

Congenital limb deficiencies (CLDs) are a relatively common group of birth defects whose etiology is mostly unknown. Recent studies suggest maternal air pollution exposure as a potential risk factor.

Aim

To investigate the relationship between ambient air pollution exposure during early pregnancy and offspring CLDs.

Methods

The study population was identified from the National Birth Defects Prevention Study, a population-based multi-center case-control study, and consisted of 615 CLD cases and 5,701 controls with due dates during 1997 through 2006. Daily averages and/or maxima of six criteria air pollutants (particulate matter <2.5 μm [PM_2.5], particulate matter <10 μm [PM₁₀], nitrogen dioxide [NO₂], sulfur dioxide [SO₂

SUBMITTER: Choi G 

PROVIDER: S-EPMC6842662 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature