Dataset Information
Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.
Ontology highlight
ABSTRACT: Objectives
The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression.Methods
The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life depression.Results
Higher SASP index was significantly correlated with older age (r = 0.42, p = 0.001) and worse executive function performance (r = -0.27, p = 0.04). After controlling for the effect of age, overall cognitive performance, and white matter hyperintensities, the association between SASP and left and right cingulate bundle mean diffusivity remained statistically significant.Conclusions
Our data suggest that, in the context of late-life depression, SASP proteins are associated with microstructural abnormalities in white matter tracts in brain and worse executive function performance.
SUBMITTER: Mendes-Silva AP
PROVIDER: S-EPMC6842685 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20190622 12
<h4>Objectives</h4>The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression.<h4>Methods</h4>The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life depression.<h4>Results</h4>Higher S ...[more]