Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by mucosal inflammation in the nose and paranasal sinuses. Inflammation in CRS is also heterogeneous and is mainly characterized by type 2 (T2) inflammation, but subsets of patients show type 1 (T1) and type 3 (T3) inflammation. Whether inflammatory endotypes are associated with clinical phenotypes has yet to be explored in detail.

Objective

To identify associations between inflammatory endotypes and clinical presentations in CRS.

Methods

We compared 121 patients with nonpolypoid CRS (CRSsNP) and 134 patients with polypoid CRS (CRSwNP) and identified inflammatory endotypes using markers including IFN-γ (T1), eosinophil cationic protein (T2), Charcot-Leyden crystal galectin (T2), and IL-17

SUBMITTER: Stevens WW 

PROVIDER: S-EPMC6842686 | biostudies-literature | 2019 Nov - Dec

REPOSITORIES: biostudies-literature