Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection.

ABSTRACT:

Introduction

Stroke-associated pneumonia (SAP) is a major cause of mortality in patients who have suffered from severe ischemic stroke. Although multifactorial in nature, stroke-induced immunosuppression plays a key role in the development of SAP. Previous studies using a murine model of transient middle cerebral artery occlusion (tMCAO) have shown that focal ischemic stroke induction results in functional defects of lymphocytes in the spleen, thymus, and peripheral blood, leading to spontaneous bacterial infection in the lungs without inoculation. However, how ischemic stroke alters immune cell niche and the expression of cytokines and chemokines in the lungs has not been fully characterized.

Methods

Ischemic stroke was induced in mice by tMCAO. Immune cell profiles in the

SUBMITTER: Farris BY 

PROVIDER: S-EPMC6842816 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature