Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome.

ABSTRACT:

Introduction

The etiology of irritable bowel syndrome (IBS) remains elusive even though several genetic and environmental pathogenic factors have been reported. IBS is considered to be a functional disorder without any detectable lesions in the patient's bowel. However, many studies have demonstrated that a subset of IBS patients have low-grade inflammation and aberrant T-cell activation in their intestinal mucosa. To elucidate the immune mechanism underlying the mucosal inflammation in IBS, we focused on dental metal hypersensitivity, a T cell-mediated, delayed-type allergic reaction that causes oral contact mucositis and systemic cutaneous inflammation.

Methods

We recruited 147 Japanese IBS patients and 22 healthy controls (HCs). The subjects underwent the in vitro lymphoc

SUBMITTER: Kageyama Y 

PROVIDER: S-EPMC6842818 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature