Gene drive for population genetic control: non-functional resistance and parental effects.

ABSTRACT: Gene drive is a natural process of biased inheritance that, in principle, could be used to control pest and vector populations. As with any form of pest control, attention should be paid to the possibility of resistance evolving. For nuclease-based gene drive aimed at suppressing a population, resistance could arise by changes in the target sequence that maintain function, and various strategies have been proposed to reduce the likelihood that such alleles arise. Even if these strategies are successful, it is almost inevitable that alleles will arise at the target site that are resistant to the drive but do not restore function, and the impact of such sequences on the dynamics of control has been little studied. We use population genetic modelling of a strategy targeting a female fertility

SUBMITTER: Beaghton AK 

PROVIDER: S-EPMC6842858 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature