Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion.

ABSTRACT: Androgen depletion in humans leads to significant atrophy of the limb muscles. However, the pathways by which androgens regulate limb muscle mass are unclear. Our laboratory previously showed that mitochondrial degradation was related to the induction of autophagy and the degree of muscle atrophy following androgen depletion, implying that decreased mitochondrial quality contributes to muscle atrophy. To increase our understanding of androgen-sensitive pathways regulating decreased mitochondrial quality, total RNA from the tibialis anterior of sham and castrated mice was subjected to microarray analysis. Using this unbiased approach, we identified significant changes in the expression of genes that compose the core molecular clock. To assess the extent to which androgen depletion altered t

SUBMITTER: Rossetti ML 

PROVIDER: S-EPMC6842919 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature