Kidney dopamine D₁-like receptors and angiotensin 1-7 interaction inhibits renal Na⁺ transporters.

ABSTRACT: The role of dopamine D₁-like receptors (DR) in the regulation of renal Na⁺ transporters, natriuresis, and blood pressure is well established. However, the involvement of the angiotensin 1-7 (ANG 1-7)-Mas receptor in the regulation of Na⁺ balance and blood pressure is not clear. The present study aimed to investigate the hypothesis that ANG 1-7 can regulate Na⁺ homeostasis by modulating the renal dopamine system. Sprague-Dawley rats were infused with saline alone (vehicle) or saline with ANG 1-7, ANG 1-7 antagonist A-779, DR agonist SKF38393, and antagonist SCH23390. Infusion of ANG 1-7 caused significant natriuresis and diuresis compared with saline alone. Both natriuresis and diuresis were blocked by A-779 and SCH23390. SKF38393 caused a signifi

SUBMITTER: Banday AA 

PROVIDER: S-EPMC6843046 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature